Jentsch H, Pomowski R, Kundt
G, Göcke R.
Treatment of gingivitis with hyaluronan, J Clin
Periodontol 2003; 30: 159-164 © Blackwell
Munksgaard, 2003.
Abstract
Objectives: Hyaluronic acid (hyaluronan) is a glycosaminoglycan
with anti-in-flammatory and antiedematous properties.
It was evaluated in a gel formulation for its
effect in the treatment of plaque-induced gingivitis.
Method: In a randomised double-blind study, 50
male subjects with plaque-induced gingivitis were
divided into two groups and used a verum or placebo
gel twice daily additionally to oral hygiene for
a 3-week treatment period. Clinical indices (API,
Turesky index, PBI) and crevicular fluid variables
(peroxidase, lysozyme) were determined at baseline
and after 4, 7, 14 and 21 days, respectively.
Results: Significant improvements
could be found for all clinical variables in both
groups. The
verum group showed significant improvement in
the study area for the plaque indices beginning
with
day 4 (P = 0.011) and the PBI beginning with
day 7 (P = 0.001) in comparison with the placebo
group.
The crevicular fluid variables were significantly
improved in the centre of the studied inflammation
area in the verum group. Here all studied sites
had significant decreases in peroxidase (176.72 – 128.75
and 188.74 – 128.75 U/L) and lysozyme (1.27 – 0.27
and 1.30 – 0.33 mg/L) activities after 7,
14 and 21 days (P between 0.034 and <0.001),
whereas in the placebo group only one site showed
a significant decrease for lysozyme (1.74 – 0.75mg/L)
after 7 and 21 days (P = 0.048 and 0.025).
Conclusions: These data suggest
that a hyaluronan containing gel has a beneficial
effect in the
treatment of plaque-induced gingivitis. Key words: clinical trial; crevicular fluid; gingivitis;
hyaluronan
Accepted for publication 11 February 2002.
Reference
Journal of Clinical Periodontology 2003, 30: 159-164,
Printed in Denmark
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Gengigel
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